Jennifer Tuscher’s Publications

Temporally specific gene expression and chromatin remodeling programs regulate a conserved Pdyn enhancer.

Phillips RA, Wan E, Tuscher JJ, Reid D, Drake OR, Ianov L, Day JJ.

Elife. 2023 Nov 8;12. doi: 10.7554/eLife.89993. PubMed PMID: 37938195; PubMed Central PMCID: PMC10631760.

Distinct subpopulations of D1 medium spiny neurons exhibit unique transcriptional responsiveness to cocaine.

Phillips RA 3rd, Tuscher JJ, Fitzgerald ND, Wan E, Zipperly ME, Duke CG, Ianov L, Day JJ.

Mol Cell Neurosci. 2023 Jun;125:103849. doi: 10.1016/j.mcn.2023.103849. Epub 2023 Mar 24. PubMed PMID: 36965548.

Cross-Platform Synaptic Network Analysis of Human Entorhinal Cortex Identifies TWF2 as a Modulator of Dendritic Spine Length.

Walker CK, Greathouse KM, Tuscher JJ, Dammer EB, Weber AJ, Liu E, Curtis KA, Boros BD, Freeman CD, Seo JV, Ramdas R, Hurst C, Duong DM, Gearing M, Murchison CF, Day JJ, Seyfried NT, Herskowitz JH.

J Neurosci. 2023 May 17;43(20):3764-3785. doi: 10.1523/JNEUROSCI.2102-22.2023. Epub 2023 Apr 13. PubMed PMID: 37055180; PubMed Central PMCID: PMC10198456.

Distinct roles of Bdnf I and Bdnf IV transcript variant expression in hippocampal neurons.

Bach SV, Bauman AJ, Hosein D, Tuscher JJ, Ianov L, Greathouse KM, Henderson BW, Herskowitz JH, Martinowich K, Day JJ.

bioRxiv. 2023 Apr 5;. doi: 10.1101/2023.04.05.535694. PubMed PMID: 37066216; PubMed Central PMCID: PMC10104043.

An atlas of transcriptionally defined cell populations in the rat ventral tegmental area.

Phillips RA 3rd, Tuscher JJ, Black SL, Andraka E, Fitzgerald ND, Ianov L, Day JJ.

Cell Rep. 2022 Apr 5;39(1):110616. doi: 10.1016/j.celrep.2022.110616. PubMed PMID: 35385745; NIHMSID:NIHMS1795988.

Morphine, the microbiome, and fatty acids: short chains make a big link in opioid reward.

Tuscher JJ, Day JJ.

Neuropsychopharmacology. 2021 Nov;46(12):2039-2040. doi: 10.1038/s41386-021-01093-4. Epub 2021 Jul 8. PubMed PMID: 34239049; PubMed Central PMCID: PMC8505438.

A Cre-Dependent CRISPR/dCas9 System for Gene Expression Regulation in Neurons.

Carullo NVN, Hinds JE, Revanna JS, Tuscher JJ, Bauman AJ, Day JJ.

eNeuro. 2021 Jul-Aug;8(4). doi: 10.1523/ENEURO.0188-21.2021. Print 2021 Jul-Aug. PubMed PMID: 34321217; PubMed Central PMCID: PMC8376295.

A dopamine-induced gene expression signature regulates neuronal function and cocaine response.

Savell KE, Tuscher JJ, Zipperly ME, Duke CG, Phillips RA 3rd, Bauman AJ, Thukral S, Sultan FA, Goska NA, Ianov L, Day JJ.

Sci Adv. 2020 Jun;6(26):eaba4221. doi: 10.1126/sciadv.aba4221. eCollection 2020 Jun. PubMed PMID: 32637607; PubMed Central PMCID: PMC7314536.

Blue Light-Induced Gene Expression Alterations in Cultured Neurons Are the Result of Phototoxic Interactions with Neuronal Culture Media.

Duke CG, Savell KE, Tuscher JJ, Phillips RA 3rd, Day JJ.

eNeuro. 2020 Jan/Feb;7(1). doi: 10.1523/ENEURO.0386-19.2019. Print 2020 Jan/Feb. PubMed PMID: 31879366; PubMed Central PMCID: PMC6946540.

Multigenerational epigenetic inheritance: One step forward, two generations back.

Tuscher JJ, Day JJ.

Neurobiol Dis. 2019 Dec;132:104591. doi: 10.1016/j.nbd.2019.104591. Epub 2019 Aug 27. Review. PubMed PMID: 31470104.

Infralimbic Estradiol Enhances Neuronal Excitability and Facilitates Extinction of Cocaine Seeking in Female Rats via a BDNF/TrkB Mechanism.

Yousuf H, Smies CW, Hafenbreidel M, Tuscher JJ, Fortress AM, Frick KM, Mueller D.

Front Behav Neurosci. 2019;13:168. doi: 10.3389/fnbeh.2019.00168. eCollection 2019. PubMed PMID: 31417375; PubMed Central PMCID: PMC6684748.

Chemogenetic Suppression of Medial Prefrontal-Dorsal Hippocampal Interactions Prevents Estrogenic Enhancement of Memory Consolidation in Female Mice.

Tuscher JJ, Taxier LR, Schalk JC, Haertel JM, Frick KM.

eNeuro. 2019 Mar-Apr;6(2). doi: 10.1523/ENEURO.0451-18.2019. eCollection 2019 Mar-Apr. PubMed PMID: 31016230; PubMed Central PMCID: PMC6477593.

A Neuron-Optimized CRISPR/dCas9 Activation System for Robust and Specific Gene Regulation.

Savell KE, Bach SV, Zipperly ME, Revanna JS, Goska NA, Tuscher JJ, Duke CG, Sultan FA, Burke JN, Williams D, Ianov L, Day JJ.

eNeuro. 2019 Jan-Feb;6(1). doi: 10.1523/ENEURO.0495-18.2019. eCollection 2019 Jan-Feb. PubMed PMID: 30863790; PubMed Central PMCID: PMC6412672.

Chemogenetic inactivation of the dorsal hippocampus and medial prefrontal cortex, individually and concurrently, impairs object recognition and spatial memory consolidation in female mice.

Tuscher JJ, Taxier LR, Fortress AM, Frick KM.

Neurobiol Learn Mem. 2018 Dec;156:103-116. doi: 10.1016/j.nlm.2018.11.002. Epub 2018 Nov 5. PubMed PMID: 30408525; PubMed Central PMCID: PMC7310386.

Estrogenic regulation of memory consolidation: A look beyond the hippocampus, ovaries, and females.

Frick KM, Tuscher JJ, Koss WA, Kim J, Taxier LR.

Physiol Behav. 2018 Apr 1;187:57-66. doi: 10.1016/j.physbeh.2017.07.028. Epub 2017 Jul 27. Review. PubMed PMID: 28755863; PubMed Central PMCID: PMC5787049.

17β-Estradiol Potentiates the Reinstatement of Cocaine Seeking in Female Rats: Role of the Prelimbic Prefrontal Cortex and Cannabinoid Type-1 Receptors.

Doncheck EM, Urbanik LA, DeBaker MC, Barron LM, Liddiard GT, Tuscher JJ, Frick KM, Hillard CJ, Mantsch JR.

Neuropsychopharmacology. 2018 Mar;43(4):781-790. doi: 10.1038/npp.2017.170. Epub 2017 Aug 21. PubMed PMID: 28825421; PubMed Central PMCID: PMC5809785.

Inhibition of local estrogen synthesis in the hippocampus impairs hippocampal memory consolidation in ovariectomized female mice.

Tuscher JJ, Szinte JS, Starrett JR, Krentzel AA, Fortress AM, Remage-Healey L, Frick KM.

Horm Behav. 2016 Jul;83:60-67. doi: 10.1016/j.yhbeh.2016.05.001. Epub 2016 May 10. PubMed PMID: 27178577; PubMed Central PMCID: PMC4915975.

Estradiol-Mediated Spine Changes in the Dorsal Hippocampus and Medial Prefrontal Cortex of Ovariectomized Female Mice Depend on ERK and mTOR Activation in the Dorsal Hippocampus.

Tuscher JJ, Luine V, Frankfurt M, Frick KM

J Neurosci. 2016 Feb 3;36(5):1483-9. doi: 10.1523/JNEUROSCI.3135-15.2016. PubMed PMID: 26843632; PubMed Central PMCID: PMC4737764.

The genome of the vervet (Chlorocebus aethiops sabaeus).

Warren WC, Jasinska AJ, García-Pérez R, Svardal H, Tomlinson C, Rocchi M, Archidiacono N, Capozzi O, Minx P, Montague MJ, Kyung K, Hillier LW, Kremitzki M, Graves T, Chiang C, Hughes J, Tran N, Huang Y, Ramensky V, Choi OW, Jung YJ, Schmitt CA, Juretic N, Wasserscheid J, Turner TR, Wiseman RW, Tuscher JJ, Karl JA, Schmitz JE, Zahn R, O'Connor DH, Redmond E, Nisbett A, Jacquelin B, Müller-Trutwin MC, Brenchley JM, Dione M, Antonio M, Schroth GP, Kaplan JR, Jorgensen MJ, Thomas GW, Hahn MW, Raney BJ, Aken B, Nag R, Schmitz J, Churakov G, Noll A, Stanyon R, Webb D, Thibaud-Nissen F, Nordborg M, Marques-Bonet T, Dewar K, Weinstock GM, Wilson RK, Freimer NB.

Genome Res. 2015 Dec;25(12):1921-33. doi: 10.1101/gr.192922.115. Epub 2015 Sep 16. PubMed PMID: 26377836; PubMed Central PMCID: PMC4665013.

Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents.

Frick KM, Kim J, Tuscher JJ, Fortress AM.

Learn Mem. 2015 Sep;22(9):472-93. doi: 10.1101/lm.037267.114. Print 2015 Sep. Review. PubMed PMID: 26286657; PubMed Central PMCID: PMC4561402.

Regulation of object recognition and object placement by ovarian sex steroid hormones.

Tuscher JJ, Fortress AM, Kim J, Frick KM.

Behav Brain Res. 2015 May 15;285:140-57. doi: 10.1016/j.bbr.2014.08.001. Epub 2014 Aug 15. Review. PubMed PMID: 25131507; PubMed Central PMCID: PMC4329280.

Bidirectional effects of inhibiting or potentiating NMDA receptors on extinction after cocaine self-administration in rats.

Hafenbreidel M, Rafa Todd C, Twining RC, Tuscher JJ, Mueller D.

Psychopharmacology (Berl). 2014 Dec;231(24):4585-94. doi: 10.1007/s00213-014-3607-1. Epub 2014 May 22. PubMed PMID: 24847958; PubMed Central PMCID: PMC4233003.

Canonical Wnt signaling is necessary for object recognition memory consolidation.

Fortress AM, Schram SL, Tuscher JJ, Frick KM.

J Neurosci. 2013 Jul 31;33(31):12619-26. doi: 10.1523/JNEUROSCI.0659-13.2013. PubMed PMID: 23904598; PubMed Central PMCID: PMC6618550.

17β-estradiol is necessary for extinction of cocaine seeking in female rats.

Twining RC, Tuscher JJ, Doncheck EM, Frick KM, Mueller D.

Learn Mem. 2013 May 15;20(6):300-6. doi: 10.1101/lm.030304.113. PubMed PMID: 23676202.

Phenotype, distribution and alloreactive properties of memory T cells from cynomolgus monkeys.

Nadazdin O, Boskovic S, Murakami T, O'Connor DH, Wiseman RW, Karl JA, Tuscher JJ, Sachs DH, Madsen JC, Tocco G, Kawai T, Cosimi AB, Benichou G.

Am J Transplant. 2010 Jun;10(6):1375-84. doi: 10.1111/j.1600-6143.2010.03119.x. Epub 2010 May 14. PubMed PMID: 20486921; PubMed Central PMCID: PMC2893326.

MHC heterozygote advantage in simian immunodeficiency virus-infected Mauritian cynomolgus macaques.

O'Connor SL, Lhost JJ, Becker EA, Detmer AM, Johnson RC, Macnair CE, Wiseman RW, Karl JA, Greene JM, Burwitz BJ, Bimber BN, Lank SM, Tuscher JJ, Mee ET, Rose NJ, Desrosiers RC, Hughes AL, Friedrich TC, Carrington M, O'Connor DH.

Sci Transl Med. 2010 Mar 10;2(22):22ra18. doi: 10.1126/scitranslmed.3000524. PubMed PMID: 20375000; PubMed Central PMCID: PMC2865159.

Trafficking, persistence, and activation state of adoptively transferred allogeneic and autologous Simian Immunodeficiency Virus-specific CD8(+) T cell clones during acute and chronic infection of rhesus macaques.

Bolton DL, Minang JT, Trivett MT, Song K, Tuscher JJ, Li Y, Piatak M Jr, O'Connor D, Lifson JD, Roederer M, Ohlen C.

J Immunol. 2010 Jan 1;184(1):303-14. doi: 10.4049/jimmunol.0902413. Epub 2009 Nov 30. PubMed PMID: 19949089; PubMed Central PMCID: PMC2797565.

Major histocompatibility complex genotyping with massively parallel pyrosequencing.

Wiseman RW, Karl JA, Bimber BN, O'Leary CE, Lank SM, Tuscher JJ, Detmer AM, Bouffard P, Levenkova N, Turcotte CL, Szekeres E Jr, Wright C, Harkins T, O'Connor DH.

Nat Med. 2009 Nov;15(11):1322-6. doi: 10.1038/nm.2038. Epub 2009 Oct 11. PubMed PMID: 19820716; PubMed Central PMCID: PMC2824247.

Identification of novel MHC class I sequences in pig-tailed macaques by amplicon pyrosequencing and full-length cDNA cloning and sequencing.

O'Leary CE, Wiseman RW, Karl JA, Bimber BN, Lank SM, Tuscher JJ, O'Connor DH.

Immunogenetics. 2009 Oct;61(10):689-701. doi: 10.1007/s00251-009-0397-4. Epub 2009 Sep 24. PubMed PMID: 19777225; PubMed Central PMCID: PMC2813950.